Acne symptoms and impact of acne on social functioning, emotional functioning, and activities of daily living (ADL) among patients with moderate to severe non-nodular Acne Vulgaris (AV) in community practices across the U.S

Objective: Evaluate patient self-perceived AV symptoms and impact of on emotional/social functioning ADL, among patients in community practices across the U.S. Methods: Single-arm, prospective cohort study (PROSES: NCT04820673) was conducted with moderate-to-severe non-nodular >9yrs who were prescribed sarecycline real-world U.S practices. Validated ASIS questionnaire (with Signs Impact (emotional & social) domains) an Expert Panel Questionnaire (EPQ; emotional (items 1-4), social 5-7), ADL 8-11)) completed by (>12yrs) caregivers (for 9-11yrs) at baseline week-12. All items scored five-point adjectival response scale (score: 0 (never/not all) – 4 (all time/very much/extremely)); a higher domain score indicate severe or negative AV. scores proportion reporting score=2/3/4 (moderate to high burden/impact parent understanding (EPQ10)) for EPQ analyzed. Results: A total 253 (pediatric: 39.92%; female: 66.40%; moderate AV: 86.56%; 13.44%). At baseline, reported burden most domains, as depicted following score: signs: 1.96, impact: 2.06, subdomain: 2.43; 0.98. From items, burden) were: patients’ mood/anger (EPQ1) 56.13%; worries about worsening (EPQ2) 79.45%; thinking acne (EPQ3) 84.19%; level (EPQ4) 72.73; media/’selfie’ activity (EPQ5) 51.38%; real-life plans (EPQ6) 44.66%; efforts hide (EPQ7) 72.73%; picked-on/judged due (EPQ8) 26.88%; ability reach future goals (EPQ9) 27.27%; sleep (EPQ11) 27.67%; concerns patients<18yrs; EPQ10) 84.16%. Conclusion: Moderate observed this Emotional especially more pronounced population.